Astroglial connexins in epileptogenesis

The astroglial network connected through gap junctions assembling from connexins physiologically balances the concentrations of ions and neurotransmitters around neurons. Astrocytic dysfunction has been associated with many neurological disorders including epilepsy. Dissociated result in increased activity connexin hemichannels which triggers brain pathophysiological changes. Previous studies patients animal models epilepsy indicate that reduced junction coupling assembled astrocytes may play an important role epileptogenesis. This abnormal cell-to-cell communication is now emerging as feature pathologies being considered a novel therapeutic target for controlling In particular, candidate drugs ability inhibition hemichannel enhancement formation should be explored to prevent epileptogenesis control